Amount of money bet: If a ton of money is already bet on one side, oddsmakers can move the line to even things out for that reason alone.If the Chiefs are 10 point favorites going into a week, and then we learn that Patrick Mahomes injured himself in practice and is now questionable, you’ll see that spread drop significantly. Injuries: Games, specifically basketball or football games can be significantly changed due to key injuries.How popular the team is: Nationally popular teams like Duke Basketball, The Dallas Cowboys, the LA Lakers, the New York Yankees, or Alabama Football receive a lot of betting interest, so oddsmakers may move the spread against them to ensure enough people are betting on both sides.